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EC number: 231-793-3 | CAS number: 7733-02-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Zinc sulphate is a severe eye irritant but not a skin irritant based on animal eye and skin irritation studies
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Used in risk assessment report for ZnSO4, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No information
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- Approximately 98.1 mg of the test material
- Duration of treatment / exposure:
- Single instillation, no eye wash
- Observation period (in vivo):
- At 1, 24, 48 and 72 hours, 7, 14 and 21 days after exposure.
- Number of animals or in vitro replicates:
- Three male animals
- Details on study design:
- No further details
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- ca. 2
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 2.7
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- ca. 2.7
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- ca. 2.7
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- ca. 3.7
- Max. score:
- 4
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Corneal injury was seen as slight dulling of the normal lustre (opacity grade 0) and/or epithelial damage (10% of the corneal area) in two animals. This injury had resolved within 24 hours in one animal and within 72 hours in the other animal.
Irritation of the conjuctivae was seen as redness (mean scores over 24-72 hours 2, 2.7 and 2.7), chemosis (mean scores 2, 2.7 and 3.7) and discharge.
Yellow/white spots were observed in the tissue of the lower eyelid, nictitating membrane and/or sclera in all animals from day 7 until termination. These spots were described as signs of necrosis and consisted of encapsulated material of unknown origin which caused protrusions at termination of the study. - Other effects:
- Reduced elasticity of the eyelids was noted in one animal, 72 hours and 7 days after instillation.
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the degree and persistence of the corneal injury, zinc sulphate is considered to cause severe ocular irritation
- Executive summary:
In a well-performed eye irritation/corrosion study, conducted according to Directive 92/69/EEC B.5 and OECD guideline 405, three male New Zealand White rabbits were treated by instillation of approximately 98.1 mg of zinc sulphate (ZnSO4.7H2O) into the conjuctival sac of one eye. The other eye remained untreated and served as control. The eyes (unrinsed) were examined at 1, 24, 48 and 72 hours and 7, 14 and 21 days after instillation.
No symptoms of systemic toxicity were observed and no mortality occurred.
Corneal injury was seen as slight dulling of the normal lustre (opacity grade 0) and/or epithelial damage (10% of the corneal area) in two animals. This injury had resolved within 24 hours in one animal and within 72 hours in the other animal.
Irritation of the conjuctivae was seen as redness (mean scores over 24-72 hours 2, 2.7 and 2.7), chemosis (mean scores 2, 2.7 and 3.7) and discharge.
Yellow/white spots were observed in the tissue of the lower eyelid, nictitating membrane and/or sclera in all animals from day 7 until termination. These spots were described as signs of necrosis and consisted of encapsulated material of unknown origin which caused protrusions at termination of the study. Reduced elasticity of the eyelids was noted in one animal, 72 hours and 7 days after instillation.
Based on the degree and persistence of the corneal injury, zinc sulphate is considered to cause severe ocular irritation.
Reference
None
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The soluble zinc compounds (i. e., zinc chloride, zinc sulphate and diammonium tertachlorozincate), displayed in vivo varying degrees of skin and eye irritation ranging from moderate to severely irritating.
Based on the available data of the soluble zinc compounds, soluble zinc chloride is classified as corrosive (C; R34) according to EC criteria due to severe skin irritancy seen in animals at concentrations of 1% solution and irreversible damage to eyes caused by zinc chloride after accidental exposure in humans. Zinc chloride has also shown signs of respiratory tract irritation in single exposure studies (see acute inhalation toxicity).
On the other hand zinc sulphate was not irritating to skin but is a severe eye irritant and has been classified as a severe eye irritant (Xi R41) according to EC criteria.
In vitro data shows that zinc bis(dihydrogen phosphate) was not irritating to skin. While no in vivo data exists on zinc bis(dihydrogen phosphate), in vitro data suggests zinc bis(dihydrogen phosphate) is moderately irritating to eyes. Diammonium tetrachlorozincate appears to be a moderate eye irritant however no classification has been assigned. While no specific irritation data were identified for triammonium pentachlorozincate, it is (due to its similar solubility characteristics) likely to display a toxicity profile similar to that of the soluble diammonium tetrachlorozincate.
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Zinc sulphate was not irritating to skin but is a severe eye irritant and has been classified as a severe eye irritant (Xi R41) or Eye Damage 1; H318 according to EC criteria.
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