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EC number: 265-084-5 | CAS number: 64741-82-8 A complex combination of hydrocarbons from the distillation of the products from a thermal cracking process. It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly in the range of C10 through C22 and boiling in the range of approximately 160°C to 370°C (320°F to 698°F).
In the key study (Klimisch score = 2,API 1985b), 10 male Hartley albino guinea pigs were dermally exposed to light catalytically cracked distillate in an induction phase and then a subsequent challenge dose. Undiluted test material was applied under occlusion at a dose volume of 0.4 mL in all instances. One control animal was found dead on day 16. Following the challenge application, very slight erythema was present in three of the nine surviving animals. The other test animals exhibited no reaction following challenge treatment. The naïve control group also exhibited very slight erythema in three of the control animals, indicating a lack of a sensitising response in the treated animals.
In five supporting studies, cracked gas oils were not found to be sensitisers to guinea pigs.
Based on these results, cracked gas oils are not skin sensitisers when tested using a closed patch technique in guinea pigs.
Migrated from Short description of key information:
Cracked gas oils are not skin sensitisers when tested using a closed patch technique in guinea pigs.
Justification for selection of skin sensitisation endpoint:
One of six studies showing no effect
Cracked gas oils are not classified as skin sensitisers according to EU CLP Regulation (EC No. 1272/2008) criteria.
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