Registration Dossier

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Based on a statistically significant reduction of fish weight the MATC (maximum acceptable toxicant concentration) of 1,2-dichloroethane in a fathead minnow early life stage test was 29 - 59 mg/L based on measured concentrations.

Key value for chemical safety assessment

Additional information

The key study was selected as the study shows the lowest toxicity endpoint.

The effects of 1,2-dichloroethane on the early life stages of fathead minnow (Pimephales promelas) were determined under continuous-flow conditions for 32 days. A dilution water control and nominal test item concentrations of 4.0, 7.0, 14.0, 29.0, and 59.0 mg/L were used during the study.

Based on a statistically significant reduction of fish weight the MATC (maximum acceptable toxicant concentration) of 1,2-dichloroethane in a fathead minnow early life stage test was 29 - 59 mg/L on measured concentrations.

Further on, the following additional information on long-term toxicity to fish is available, but is not considered as reliable:

Species

NOEC

Author

Oncorhynchus kisutch

56 mg/L (LOEC) after 21 d

Reid, B.J.et al.(1982)

Oncorhynchus mykiss

0.2 mg/L after 27 d

Black, J.Aet al.(1982)

The effect values found by Black et al. for several substances are usually very low compared to effect values by other authors. No explanation for these large discrepancies could be found. A careful examination of the entire information provided by Black et al. gave no plausible reason for the inconsistency of the data. However, as it was not possible to reproduce the effect values found by Black and his co-workers, it is proposed not to use these data for a derivation of a PNECaqua if other valid fish early life stage tests are available.

Reference List

Black, J.A. et al. (1982): NTIS/PB 82-224601.

Reid, B.J. Morgan J.D., Whelen, M.A. (1982): A preliminary examination of the effects of ethylene dichloride on the hatchability of coho salmon eggs (oncorhynchus kisutch); Can. Techn. Rep. Fish. Aquat. Sci. 1163, 145-153.