Registration Dossier

Administrative data

Description of key information

Two acute oral toxicity studies using rats have been conducted for two of the FLL Samples with both indicating low toxicity with an LD50≥ 2000 mg/kg bw. In both tests, 2000 mg/kg bw was the highest dosing rate and no mortalities were observed at this dose, meaning that a NOAEL of 2000 mg/kg bw can also be inferred. The LD50 limit value does not fall below the criterion of 2000 mg/kg bw for Category 4 with respect to acute oral toxicity classification indicating that the FLL Substances do not pose an acute toxicity hazard.Two acute dermal toxicity studies using rats have been conducted for two of the FLL Samples with both indicating low toxicity with an LD50≥ 2000 mg/kg bw. In both tests, 2000 mg/kg bw was the highest dosing rate and no mortalities were observed at this dose, meaning that a NOAEL of 2000 mg/kg bw can also be inferred. The LD50 limit value does not fall below the criterion of 2000 mg/kg bw for Category 4 with respect to acute dermal toxicity classification indicating that the FLL Substances do not pose an acute toxicity hazard

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Justification for classification or non-classification

ORAL:

The LD50 limit value does not fall below the criterion of 2000 mg/kg bw for Category 4 with respect to acute oral toxicity classification indicating that the FLL Substances do not pose an acute toxicity hazard.

DERMAL:

The LD50 limit value does not fall below the criterion of 2000 mg/kg bw for Category 4 with respect to acute dermal toxicity classification indicating that the FLL Substances do not pose an acute toxicity hazard.