Registration Dossier
Registration Dossier
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EC number: 269-052-1 | CAS number: 68186-90-3 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77310.
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: unsuitable test system for a solid test substance
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
- Reference Type:
- secondary source
- Title:
- C.I. Pigment Brown 24
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 15
Materials and methods
- Principles of method if other than guideline:
- The inhalation hazard test (IHT; synonymous to IRT, inhalation hazard test) was performed in principle as described in OECD Guideline 403 and in accordance to Smyth et al., Am.Ind.Hyg.Ass.J. 23,95-107 (1962). The aim of the test was to demonstrate the toxicity of an atmosphere saturated with vapors of the volatile components of the test substance at a temperature chosen for vapor generation (i.e. 20 °C for the present test substance).
The animals were exposed to the test substance for 7 hours (flow-through, 200 liters/hour). - GLP compliance:
- no
- Test type:
- other: IHT
Test material
- Reference substance name:
- Chrome antimony titanium buff rutile
- EC Number:
- 269-052-1
- EC Name:
- Chrome antimony titanium buff rutile
- Cas Number:
- 68186-90-3
- Molecular formula:
- (Ti, Sb, Cr) O2
- IUPAC Name:
- manganese(4+) trititanium(4+) pentaantimony(3+) chromium(3+) nickel(2+) octadecaoxidandiide
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males 190 g/ females 170 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- The nominal concentration was recalculated regarding the air flow and the test substance loss
- Duration of exposure:
- 7 h
- Concentrations:
- 0.1 mg/l
- No. of animals per sex per dose:
- 6
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- other: IHT
- Remarks on result:
- other: No mortality within 7 hours in a saturated atmosphere.
- Mortality:
- none
- Clinical signs:
- other: nothing abnormal observed
- Gross pathology:
- nothing abnormal observed
Applicant's summary and conclusion
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