Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DMEL (Derived Minimum Effect Level)
Value:
2.21 mg/m³
Most sensitive endpoint:
carcinogenicity
DNEL related information
Overall assessment factor (AF):
1
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1 530 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
3
Dose descriptor:
NOAEC
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible

Workers - Hazard for the eyes

Additional information - workers

A DN(M)EL for acute effects should be derived if an acute hazard leading to acute toxicity (eg. C&L) has been identified and there is a potential for high peak exposures. This is not the case with members of this category.

 The marker substances with the highest relative hazard potential were selected. Long term systemic effects are therefore defined by the carcinogenicity of 1,3-butadiene in humans and long term local effects by nasal lesions caused by 2-methylpropene in rats. The DN(M)ELs of 2.21 and 1530 mg/m3 are equivalent to 1 and 667 ppm respectively.

 

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DMEL (Derived Minimum Effect Level)
Value:
0.066 mg/m³
Most sensitive endpoint:
carcinogenicity
DNEL related information
Overall assessment factor (AF):
1
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
918 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
5
Dose descriptor:
NOAEC
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

A DMEL for acute effects should be derived if an acute hazard leading to acute toxicity (eg. C&L) has been identified and there is a potential for high peak exposures. This is not the case with members of this category.

The marker substances with the lowest DN(M)ELs were selected for population effects as these are most protective. Long term systemic effects are therefore defined by the carcinogenicity of 1,3-butadiene in humans and long term local effects by nasal lesions caused by 2-methylpropene in rats. The DN(M)ELs of 0.0664 and 1530 mg/m3 are equivalent to 30 ppb and 400 ppm respectively.

The main use of hydrocarbon streams are as intermediates and monomers, hence exposure of the general population is likely to be low.