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EC number: 201-052-9 | CAS number: 77-73-6
Skin irritation scores according to the Draize scheme
Erythema (Test/Control sites)
Oedema (Test/Control sites)
after 1 hour
after 24 hours
after 48 hours
after 72 hours
mean scores 24-72h
Overall mean score (24-72 h)
Well-defined erythema persisted at all treated skin sites at 24, 48 and 72 hour observations. Signs of possible hyperkeratinisation were noted on day 7. No oedema was noted on day 7. No other adverse dermal reactions were noted during the study.
Skin irritation was assessed in a group of 3 New Zealand white rabbits. 0.5 mL of dicyclopentadiene 75% was applied to an area of clipped, intact skin under a semi-occlusive dressing for 4 hours. Animals were observed at 1 and 4 hours after removal of the patch and then daily for 7 days. Well-defined erythema and slight to severe oedema was present at skin sites of all rabbits at 24, 48 and 72 hour observations. On day 7 no oedema was noted but there were signs of possible hyperkeratinisation. No other adverse dermal reactions were noted during the study. The overall mean scores (24, 48 & 72 hr) were 2 for erythema and 2.3 for oedema, and the mean oedema score exceeded 2.3 for two of the three animals. DCPD 75% was a therefore considered a moderate irritant to rabbit skin and, according to EEC labelling regulations, the symbol "Xi" and risk phrase R38 "IRRITATING TO SKIN" are required.
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