Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-052-9
CAS number: 77-73-6
irritation scores according to the Draize scheme
Erythema (Test/Control sites)
Oedema (Test/Control sites)
after 1 hour
after 24 hours
after 48 hours
after 72 hours
mean scores 24-72h
Overall mean score (24-72 h)
erythema persisted at all treated skin sites at 24, 48 and 72 hour
observations. Signs of possible hyperkeratinisation were noted on day 7.
No oedema was noted on day 7. No
other adverse dermal reactions were noted during the study.
irritation was assessed in a group of 3 New Zealand white rabbits. 0.5
mL of dicyclopentadiene 75% was applied to an area of clipped, intact
skin under a semi-occlusive dressing for 4 hours. Animals were observed
at 1 and 4 hours after removal of the patch and then daily for 7 days.
Well-defined erythema and slight to severe oedema was present at skin
sites of all rabbits at 24, 48 and 72 hour observations. On day 7 no
oedema was noted but there were signs of possible hyperkeratinisation.
No other adverse dermal reactions were noted during the study. The
overall mean scores (24, 48 & 72 hr) were 2 for erythema and 2.3 for
oedema, and the mean oedema score exceeded 2.3 for two of the three
75% was a therefore considered a moderate irritant to rabbit skin,
therefore, classification as H315 "causes skin irritation", according to
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again