Registration Dossier
Registration Dossier
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EC number: 231-113-5 | CAS number: 7440-03-1
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to birds: reproduction test
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
The substance is not considered to cause toxic effects in birds.
Key value for chemical safety assessment
Additional information
As the test substance is not classified as toxic or harmful to mammals, the substance is also not considered to cause toxic effects in birds. Elemental niobium is physiologically inert. The toxico-kinetic behavior of niobium shows no absorption takes place even after oral ingestion. In artificial solutions, mimicking physiological relevant exposure condition’s in the body (i.e. artificial - sweat solution and - gastric fluid) niobium was found to be hardly soluble (see technical dossier chapter 7.1 on toxico-kinetics). In consequence, niobium is not bioavailable under physiological relevant conditions. Thus, a study with birds is scientifically unjustified. Taking also in consideration animal welfare reasons, testing with birds will be omitted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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