Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: publication in review style. No details available

Data source

Reference
Reference Type:
review article or handbook
Title:
Comparative Pharmacology of Menthol and its Isomers
Author:
Macht DI, Phar D
Year:
1939
Bibliographic source:
Arch. int. Pharmacodyn.(1939) 43-58

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A 5 per cent solution of L Menthol in olive oil was prepared and administered intraperitoneal or hypodermic.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
L-menthol
EC Number:
218-690-9
EC Name:
L-menthol
Cas Number:
2216-51-5
Molecular formula:
C10H20O
IUPAC Name:
2-isopropyl-5-methylcyclohexanol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
olive oil
Details on exposure:
single intraperitoneal application
Doses:
5% in olive oil
No. of animals per sex per dose:
unknown
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: Lethal dose
Effect level:
1.5 other: mg/g body weight
Based on:
dissolved
Mortality:
no data
Clinical signs:
The oily solutions injected intraperitoneally or hypodermically produced a primary excitation followed by depression changing grandually into coma and ending in death from paralysis of the respiration.
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Conclusions:
No conclusion possible on this study.