Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: publication in review style. No details available

Data source

Reference
Reference Type:
review article or handbook
Title:
Comparative Pharmacology of Menthol and its Isomers
Author:
Macht DI, Phar D
Year:
1939
Bibliographic source:
Arch. int. Pharmacodyn.(1939) 43-58

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A 5 per cent solution of L Menthol in olive oil was prepared and administered intraperitoneal or hypodermic.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
L-menthol
EC Number:
218-690-9
EC Name:
L-menthol
Cas Number:
2216-51-5
Molecular formula:
C10H20O
IUPAC Name:
2-isopropyl-5-methylcyclohexanol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
olive oil
Details on exposure:
single intraperitoneal application
Doses:
5% in olive oil
No. of animals per sex per dose:
unknown
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: Lethal dose
Effect level:
1.5 other: mg/g body weight
Based on:
dissolved
Mortality:
no data
Clinical signs:
The oily solutions injected intraperitoneally or hypodermically produced a primary excitation followed by depression changing grandually into coma and ending in death from paralysis of the respiration.
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Conclusions:
No conclusion possible on this study.