Registration Dossier
Registration Dossier
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EC number: 235-123-0 | CAS number: 12070-12-1
Endpoint summary
Administrative data
Description of key information
In a semi-occlusive skin irritation study conducted on rabbits according to OECD 404, tungsten carbide (WC) elicited no dermal irritation. In an eye irritation study conducted on rabbits according to OECD 405, instillation of WC into the rabbit elicited transient very slight to well-defined conjunctival irritation only. Based on the results of this study, WC can be considered as non-irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
- Justification for type of information:
- Data waiving
Reason: Study scientifically not necessary
Justification: An in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
- Justification for type of information:
- Data waiving
Reason: Stucy scientifically not necessary
Justification: An in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available,
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
