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EC number: 235-123-0 | CAS number: 12070-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- LP guideline study. Reliability assigned by a secondary source (OECD SIDS Initial Assessment Report). Only secondary source reviewed, as primary study was not available.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
no data - Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- TEST ORGANISM:
-Mixed population of aquatic micro-organisms of a waste water treatment plant treating predominantly domestic sewage (Hildesheim, Germany); pre-treatment: washed twice with autoclaved tap water and diluted 1:3.
-Nutrient solution: synthetic waste water, pH 7.1, dry sludge concentration; 2.7 g/L. - Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- no data
- Hardness:
- no data
- Test temperature:
- 19 °C
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- Test concentration: 6 (58, 100, 180, 320, 580, 10000 mg/L)
- Details on test conditions:
- Type: aquatic
TEST CONDITIONS:
-Static test system
-Dry sludge concentration: 2700 mg/L
-Test vessels: 500 ml Erlenmeyer flasks
-Stirring period before start of incubation time: 16.5 h
-Dispersion treatment of test substance: 15 min ultrasonic bath at 30 °C
-Replicates: 1 per concentration and control
-Test parameter: respiration rate
-Aeration: permanent - Reference substance (positive control):
- yes
- Remarks:
- copper (II) sulfate pentahydrate (58, 100, 180 mg/L).
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- growth inhibition
- Details on results:
- The test substance was not soluble in water in a concentration of 1000 mg/L.
The test substance was deposited on the ground. Effects of the test concentration leading to an inhibition >20 % after 3h were not observed. The EC-values were not determinable. An EC50 of >1000 mg/L was derived from the test results. - Results with reference substance (positive control):
- The two control respiration rates differ not more than 15 %
The EC50 of the reference substance was in the accepted range (67 - 134 mg/L). - Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- yes
- Conclusions:
- An EC50 of >1000 mg/L was derived from the test results.
Reference
Description of key information
The toxicity of tungsten carbide on activated sludge, respiration inhibition was assessed. The 3h EC50 was found to be >1000 mg/L (938.7 mg W/L).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
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