Registration Dossier
Registration Dossier
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EC number: 701-257-8 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD study or GLP defined, only 4 Salmonella strains tested.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Principles of method if other than guideline:
- other: Ames assay
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
- EC Number:
- 701-257-8
- IUPAC Name:
- C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
- Test material form:
- liquid
Constituent 1
Method
- Target gene:
- Ames assay: detection of base pair substitutions and frameshift mutations
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- up to 12500 ug/plate
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- yes
- Positive controls:
- yes
- Remarks:
- s1) Endoxan (only TA 1535 and TA 100); 2) Trypaflavin (only 1537 and TA 98); 3) 2-Aminoanthrazen (only TA 1537 and TA 98)
- Positive control substance:
- other: Endoxan, Trypaflavin, 2-Aminoanthrazen
- Details on test system and experimental conditions:
- IUCLID4 Type: Ames test
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
No references for a mutagen effect of Mesamoll could be found.
Applicant's summary and conclusion
- Executive summary:
Mesamoll was tested in an Salmonella/microsome test in doses up to 12500 µg/plate (20; 100; 500; 2500; 12500 µg/plate) with 4 Salmonella typhimurium strains (TA 1535; TA 100; TA 1537 and TA 98).
Doses up to 12500 µg/plate did not lead to bacteriotoxic effects. The positive controls Endoxan, Trypaflavin and 2 -Aminoanthrazen reacted clearly mutagen.
No references for a mutagen effect of Mesamoll could be found.
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