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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 701-257-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- Principles of method if other than guideline:
- Method: other: 10 rats/group and sex
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
- EC Number:
- 701-257-8
- IUPAC Name:
- C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Bor: WISW
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: test substance administered with food
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
750; 3000; 12000 ppm (dosage males: 55.4; 228.0; 985.2 mg/kg b.w./day (calculated) dosage females: 68.7; 282.6; 1488.5 mg/kg b.w./day (calculated))
Basis:
- No. of animals per sex per dose:
- 10/sex/dose
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Water consumption and compound intake (if drinking water study):
- effects observed, treatment-related
- Ophthalmological findings:
- no effects observed
- Haematological findings:
- effects observed, treatment-related
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 3 000 ppm
- Sex:
- male/female
- Basis for effect level:
- other: In the highest dose group of 12000 ppm the female rats consumed more food and the male rats had an increased water consume and a slightly increased tromboplastin-time was observed in male rats at 12000 ppm.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RM-Freetext:
dosage males: 55.4; 228.0; 985.2 mg/kg b.w./day
(calculated)
dosage females: 68.7; 282.6; 1488.5 mg/kg b.w./day
(calculated)
no death, no effect on behaviour, reduced body weight gain, increased feed
(females) and water consumption (males) at the high dose level, absolute and
relative liver weight is significantly dose-related increased at all dose
levels, kidney weight only increased at the high dose level, no
substance-related histopathological effects (47 organs and tissue),
opthalmological, hematological and clinical- chemical parameters within the
normal range, slightly increased tromboplastin/time at the high dose.
Applicant's summary and conclusion
- Executive summary:
In a subchronical 3 month-feeding study male and female rats received the test substance via food in following doses: 0 (control-group); 750; 3000; 12000 ppm.
No mortalities and no effects on behaviour were observed.
Food and water intake were not modified up to 3000 ppm. In the highest dose group of 12000 ppm the female rats consumed more food and the male rats had an increased water consume.
The growth was delayed in male and femal rats in the highest dose group.
The absolute and relative liver weight was significantly dose-related increased at all dose levels, but the kidney weight only increased at the high dose level. No substance related histopatological effects (aorta, eyes with lids, cecum, duodenum, femur, brain, bladder, testicles, skin, heart, pituitary gland, larynx, head, ileum, jejunum, liver, lung, mesenterial lymph node, mandibular lymph node, stomach, lactiferous gland, spleen, femoral musculature, epididymis, nervus ischiadicus, nervus opticus, kidneys, esophagus, ovaries, oviduct, pancreas, prostata, rectum, cervical, thoracal and lumbal spinal cord, seminal vesicle, thyroid gland, salivary gland, sternum, thymus (if present), trachea, extraorbitary lacrimal gland, uterus, vagina, tongue) were observed.
Ophtalmological, hematological and clinical parameters were within the normal range.
Only a slightly increased tromboplastin-time was observed in male rats at 12000 ppm.
The NOAEL for male and female rats therefore is 3000 ppm.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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