Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined; no data on purity of test sample
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Principles of method if other than guideline:
other: acute i.p. toxicity study in male rats
GLP compliance:
not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Doses:
5.0 ml/kg
No. of animals per sex per dose:
10 male rats/dose
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 5 275 mg/kg bw

Any other information on results incl. tables

 Dose (ml/kg bw)  Timepoint of death  Toxicological result (Nr.of mortalities/Animals with symptoms/No.of animals)
 5.0  -  0/0/10

Applicant's summary and conclusion

Executive summary:

The acute intraperitoneal toxicity of Mesamoll was tested in male Wistar rats. The dose tested was 5.0 ml/kg bw.

No mortalities and no signs of intoxication could be observed.

Regarding the density of Mesamoll (1.055 g/cm³ at 20 °C) the LD 50 was higher than 5275 mg/kg bw.