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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined; no data on purity of test sample.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Principles of method if other than guideline:
Acute percutan toxicity in male and female rats.
GLP compliance:
not specified
Test type:
other: acute percutan toxicity in male and female rats.
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
EC Number:
701-257-8
IUPAC Name:
C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
Test material form:
liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
7 d
Doses:
1.0 ml/kg bw.
No. of animals per sex per dose:
5/sex/dose
Control animals:
not specified

Results and discussion

Effect levels
Key result
Dose descriptor:
LD50
Effect level:
> 1 055 mg/kg bw

Any other information on results incl. tables

 Dose (ml/kg bw)  sex  Timepoint of death  Toxicological result (No. of mortalities/ Animals with symptoms/ No.of animals)
 1.0  male  -  0/0/5
 1.0  female  -  0/0/5

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

In this acute dermal toxicological study Mesamoll was applied once to the shaved skin of the back of male and female Wistar rats

(160 -180 g). The observation time was 7 days and during this timeperiod the test substance was not removed from the animals. No mortalities and no symptoms of toxicity could be observed. Therefore, regarding the density of Mesamoll ( 1.055 g/cm³ at 20 °C),

the LD 50 was higher than 1055 mg/kg bw.