Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No data on purity of test sample, non-GLP
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Principles of method if other than guideline:
Acute oral toxicity in male rats
GLP compliance:
not specified
Test type:
other: Acute oral toxicity in male rats
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
EC Number:
701-257-8
IUPAC Name:
C14-17 alkanes, sec-mono- and disulfonic acids, phenyl esters
Details on test material:
no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: none
Doses:
5.0; 15.0 ml/kg bw.
No. of animals per sex per dose:
10 male rats/dose
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 15 mL/kg bw

Any other information on results incl. tables

 Dose (ml/kg bw)  Timepoint of death  Toxicological result (No.of mortalities/ Animals with Symptoms/ No.of animals)

 5.0

 -

0/0/10 

 15.0

 -

 0/10/10

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

The acute oral toxicity of Mesamoll was tested in male Wistar rats treated via gavage with the doses: 5.0 and 15.0 ml/kg bw. The observation period was 14 days. No mortalities could be observed. Signs of intoxication were observed in the 15.0 ml/kg bw dose group (apathy, ruffled fur and diarrhea). The LD 50 was higher than 15 ml/kg bw (corresponds to 15.9 g/kg).