Registration Dossier
Registration Dossier
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EC number: 212-344-0 | CAS number: 793-24-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, data from summary without detailed documentation, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of Santoflex' 13 antiozonant.
- Author:
- Randall DJ and Bannister RM
- Year:
- 1 990
- Bibliographic source:
- Acute Toxicity Data 1: 67-68
Materials and methods
- Principles of method if other than guideline:
- Method: other acute dermal toxicity study
- GLP compliance:
- no
- Test type:
- other: acute toxicity study
Test material
- Reference substance name:
- N-1,3-dimethylbutyl-N'-phenyl-p-phenylenediamine
- EC Number:
- 212-344-0
- EC Name:
- N-1,3-dimethylbutyl-N'-phenyl-p-phenylenediamine
- Cas Number:
- 793-24-8
- Molecular formula:
- C18H24N2
- IUPAC Name:
- N1-(4-methylpentan-2-yl)-N4-phenylbenzene-1,4-diamine
- Details on test material:
- IUCLID4 Test substance: other TS: purity 95.7 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: undiluted (warmed to 115°F to liquefy)
- Duration of exposure:
- 24 h
- Doses:
- 3160, 5010, 7940 mg/kg bw
- No. of animals per sex per dose:
- 1 to 2
- Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Remarks on result:
- other: reduced appetite and activity three to seven days
Any other information on results incl. tables
RS-Freetext:
MORTALITY:
-Number of deaths at each dose: no deaths
CLINICAL SIGNS:
reduced appetite and activity for 3-7 days
NECROPSY FINDINGS:
viscera appeared normal
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
