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Diss Factsheets
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EC number: 203-080-7 | CAS number: 103-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- BASF Test, observation period of 7 days
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl acrylate
- EC Number:
- 203-080-7
- EC Name:
- 2-ethylhexyl acrylate
- Cas Number:
- 103-11-7
- Molecular formula:
- C11H20O2
- IUPAC Name:
- 2-ethylhexyl acrylate
- Details on test material:
- - Test substance: 2-ethylhexyl acrylate
- Chemical name: 2-propenoic acid, 2-ethylhexyl ester
- Analytical Purity: no data
- Impurities: stabilised with 0.05 % hydrochinone
- Density: 0.887 g/cm3 (DIN 51757, cited in EU RAR, 2005)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean body weight at test start: 142.0 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous emulsion with traganth (10 %)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10 %
- Amount of vehicle (if gavage): 4.51 mL/kg bw
MAXIMUM DOSE VOLUME APPLIED: 5.01 mL/kg bw
- Doses:
- 2.040, 3.160, and 5.010 mL/kg bw (corresponding to 1809.5, 2802.9, and 4443.9 mg/kg bw)
- No. of animals per sex per dose:
- 5 animals (1809.5, 2802.9 mg/kg bw), 10 animals (4443.9 mg/kg bw)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: after 1 h, 24 h, 48 h, and 7 d
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- On the basis of the observed lethality, the LD50 value was estimated or determined using a graphical evaluation of the dose response curve on probability paper.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 435 mg/kg bw
- Mortality:
- LD50:
Original value: approx. 5.0 mL/kg bw; therefore LD50 = approx. 4435 mg/kg bw (density: 0.887 g/mL) - Clinical signs:
- other: 1809.5 mg/kg bw: on the day of administration no findings; on the following day ruffled fur. 2802.9 mg/kg bw: 2 hours after administration staggering, slight abdominal position; on the following day no clinical signs apart from ruffled fur. 4443.9 mg/kg
- Gross pathology:
- Upon necropsy no macroscopic abnormalities were found.
Any other information on results incl. tables
Mortality:
Time |
Dose level [mg/kg bw] |
||
1809.5 |
2802.9 |
4443.9 |
|
1 h |
0/5 |
0/5 |
0/10 |
24 h |
0/5 |
0/5 |
4/10 |
48 h |
0/5 |
0/5 |
4/10 |
7 d |
0/5 |
0/5 |
4/10 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Executive summary:
Administration of 10% aqueous traganth solutions of 2-EHA (stabilised with 0.05% hydroquinone, no data on purity) to rats resulted in an oral LD50 value of 5.0 ml/kg (approximately 4,430 mg/kg). Clinical signs observed were apathy, narcotic state, and diarrhoea; no histologic alterations were detected, no further data are given.
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