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Diss Factsheets
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EC number: 203-080-7 | CAS number: 103-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
see below
Additional information
1) Partition coefficient:An experimental log Pow of 4.64 (25 °C) was determined using the shake-flask method, but may represent an overestimation of the actual log Pow due to methological deficiencies. Log Pow values calculated by Q(SAR), i.e. Epi Suite SRC KOWWIN v1.67, and regression analysis, were 4.09 (BASF SE, 2008) and 3.67 (Fujisawa & Masuhara, 1981), respectively. Using a weight of evidence approach, the log Pow was estimated to be 4 indicating a potential for bioaccumulation.
2) OECD Test Guideline 305 study in Cyprinus carpio: In a study conducted with 2-Ethylhexyl Acrylate (2EHA) according to the OECD Guideline for Testing of Chemicals, No. 305, 2012, the ability of the test substance to accumulate in tissues of carp (Cyprinus carpio) was tested during an uptake phase of 28 days and a depuration phase of 56 days. The kinetic bioconcentration factor (BCFk) was determined since no steady state was reached over the test duration. A sequential determination model was applied in addition to a normalization for the standard lipid content of 5%, however, based on a poor fit of the lipid-normalized data in both the simultaneous and sequential models, along with the understanding that the parent substance is likely readily metabolised, lipid-normalization of the kinetic BCF was not further pursued with this dataset. The BCFk was determinded based on total radioactivity which includes the sum of the parent compound, possible metabolites and assimilated carbon, whereas GC-FID analysis of the extracts of the fish tissues showed no parent 2EHA. The BCFkbased on total radioactivity was 347 L/kg and the half-life (DT50) value of the total radioactivity was 19 days indicating slow depuration. The experimentally determined BCF is much lower than the cut off criterion of 2000 L/kg.
3) Empirical results and QSAR models that predict significant metabolism of 2-EHA: Significant intrinsic clearance is predicted (via multiple QSAR models) for 2-EHA indicating that the material will be rapidly metabolized and not bioaccumulated (Table 1). Support for this comes from combined evidence of metabolism observed for 2-EHA in rodent toxicokinetic studies. Briefly, metabolism rates 2-EHA in rat liver microsomes and whole rat blood were determined. 2-EHA was hydrolyzed to acrylic acid with a half-life of 2.26 minutes in rat liver microsomes with an intrinsic clearance rate of 306 µL/min/mg (Table 1). Additionally, in whole rat blood, 2-EHA was rapidly metabolized with a half-life of 3.85 minutes and an intrinsic clearance rate of 180 µL/min (The Dow Chemical Company, 2018; Table 1). Thisin vitrometabolism result indicates that 2-EHA can be quickly metabolized primarily through hydrolysis to acrylic acid and/or glutathione conjugationin vivo.
4) PBT criteria:The registered substance and its relevant degradation products are not persistent(readily biodegradable based on OECD 301 F)according to the criteria laid down under annex XIII of REACh regulation. The bioaccumulation study resulted in a BCF of 347 L/kg. Thus, none of them is PBT/vPvB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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