Registration Dossier

Administrative data

Description of key information

LD50 Acute Oral rat > 2000 mg/Kg bw
LD50 Acute Dermal rat > 5000 mg/Kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
2 000 mg/kg bw
Quality of whole database:
The study is a Klimish 1 study

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
5 000 mg/kg bw
Quality of whole database:
The study is a Klimish 1 study

Additional information

Acute toxicity studies per oral and dermal exposure have been performed on the multiconstituent substance "Reaction mass of dipotassium phosphonate and Phosphonic acid, potassium salt (1:1)" (Salvador, 2013) and the results of those studies are also applicable to the monoconstituent "mono Potassium phosphonate", which is a component and also the favourite species in the gastric environment.

No effect has been reported respectively at 2000 and 5000 mg/Kg bw for oral and dermal exposure

Justification for classification or non-classification

Oral acute toxicity

The substance is not classified for oral toxicity because it doesn't meet the classification criteria of the CLP regulation n. 1272/2008:

Oral (mg/kg bodyweight)

Category 1: ATE ≤ 5

Category 2: 5 < ATE≤ 50

Category 3: 50 < ATE≤ 300

Category 4: 300 < ATE≤ 2 000

The substance had no effect at 2000 mg/Kg bw

Inhalation acute toxicity

According to the Annex VIII of the REACH Regulation n. 1907/2006, inhalation route is not considered appropriate, based also on vapour pressure and the test can be waived.

Dermal acute toxicity

The substance is not classified for dermal toxicity because it doesn't meet the classification criteria of the CLP regulation n. 1272/2008:

Dermal (mg/kg bodyweight)

Category 1: ATE ≤ 50

Category 2: 50 < ATE≤ 2000