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EC number: 231-768-7 | CAS number: 7723-14-0
At 4 hours the radioactivity levels were in the order of liver > kidneys > lungs > spleen > bone > muscle > brain.
The toxicokinetics of radiolabelled white phosphorus were investigated in the rat using gavage administration. Radioactivity was well absorbed, with absorption essentially complete in 24 hours with 60 -65% of the administered dose. Most of the absorbed radioactivity was excreted in the urine, suggesting that the substance was metabolised since white phosphorous has limited solubility in water. Chromatography of urine samples indicated the metabolites consisted of two classes of compounds, one of which corresponded to inorganic phosphate. The liver contained high amounts of radioactivity. Skeletal muscle also contained a large percentage of the dose but this was thought to be due to the high muscle mass of the body. Only small amounts of radioactivity were found in other tissues. An additional repeat dose group indicated an accumulation of radioactivity in all tissues examined. The results of the study indicate that a proportion of the administered substance is incorporated into the phosphate pool
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