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Diss Factsheets
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EC number: 231-768-7 | CAS number: 7723-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Studies specifically on the absorption/distribution/metabolism/excretion (ADME) of this substance (Fe3P) are not available. Their conduct was considered dispensable in view of the chemical inertness and extremely poor water solubility of the substance. However, data are currently available from in vivo toxicology studies performed with this substance, supporting the above conclusion on lack of bioavailability.
Fe3P is an inorganic compound with a molecular weight of 198.5 g/mole. Its water solubility was verified to be below the limit of detection of the analytical method employed (≤ 1 mg/L). Fe3P is used as an additive for powder metallurgy. It is a dark powder containing 31% w/w particles smaller than 10 μm (respirable particulate material). These physicochemical properties suggest that Fe3P will not be readily absorbed across biological membranes.
Absorption
Oral route
The available data on the acute and repeated dose toxicity studies by the oral route does not indicate any systemic toxicity from Fe3P; there were no obvious clinical signs specific to treatment with Fe3P, the weights of examined organs after 28 days repeated oral administration were unaffected by treatment and no gross or microscopic changes were observed. This suggests that either the compound is absorbed and not toxic or it is not absorbed via the gastrointestinal tract. The abnormal colour (black) of the faeces recorded in the acute oral toxicity study in rats indeed suggests that Fe3P is not absorbed, and instead is excreted via faeces.
Dermal route
Fe3P did not show any potential to induce skin sensitization. No other data are available on absorption after dermal application. Therefore it is not possible to conclude whether Fe3P can be absorbed through skin or not. However, the physicochemical properties of the compound suggest that it is very poorly absorbed through the skin.
Inhalation route
Effects seen in an acute inhaled toxicity study were limited to the lungs and tracheobronchial lymph nodes, suggesting the possibility of a local effect. The increased lung weights are consistent with the residual test material remaining in the lungs at the end of the 14‑day recovery period, and the enlarged lymph nodes are likely to be indicative of the on-going removal of exogenous material; neither effect is particularly indicative of a systemic toxic effect, and such findings could be expected for many powders of inhalable particle size. On this basis, it is concluded that Fe3P is not readily absorbed via the lungs and that the treatment-related effects observed in the acute inhalation study are not specific to Fe3P, but instead characteristic of inert particulate material of inhalable or near-inhalable size.
Distribution, Metabolism, Excretion
Data specifically from toxicokinetics studies with Fe3P are not available. Likewise, no data are available on distribution and metabolism in the existing toxicity studies. However, there are clear indications to suggest that the substance is not readily absorbed by the gastrointestinal tract, through the lungs or the skin. Therefore it may be expected that Fe3P will not be distributed systemically or metabolised to any relevant extent. Some metabolism may occur in the gastrointestinal tract, the lungs or the skin but the majority of the substance will be excreted/removed as such. The abnormal colour (black) of the faeces recorded in the acute oral toxicity study in rats suggests that the substance will be excreted via the faeces. When administered by inhalation, it is expected that the substance will be translocated from the respiratory tract by macrophages to the extrathoratic region from where it will be swallowed.
Conclusion
There is good evidence that the test substance is not readily absorbed by the gastro intestinal tract, the skin or the lungs. Since it is not absorbed, it is not expected to be distributed to internal body tissues/organs or metabolised. It seems to be excreted via the faeces when orally administered. When inhaled, there is evidence that it is removed from the lungs involving mucocilliary mechanisms.
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