Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Data waiving:
exposure considerations
Justification for data waiving:
other:
Justification for type of information:
No studies were located regarding chronic effects after dermal exposure to cadmium metal or cadmium compounds. However, repeated dose toxicity via the dermal route is not expected to be significant as uptake of soluble and less-soluble cadmium compounds applied onto the skin of animals appears to be low (<1%) (see Section 5.1.1). Also in view of the risk reduction measures which need to be taken as a result of the carcinogenicity of cadmium metal and some of the cadmium compounds, dermal toxicity is not likely to pose an issue for human health.

Data source

Materials and methods

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion