Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
other: publication
Adequacy of study:
other information
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: It is unknown if reported study is conducted according to guideline or under GLP conditions. Publication describes method extensively, results are presented clearly.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1978

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
A possible mechanism of toxicity of a.o. aluminium chlorhydrate towards macrophages and fibroblasts is suggested.
Executive summary:

The damaging effects of some industrially important Aluminium and Zirconium compounds (a.o. aluminium chlorhydrate (ACH)) on guinea-pig macrophages and skin fibroblasts have been investigated. Cell death was measured by the release of lactate dehydrogenase activity. The haemolytic properties of these compounds has also been investigated. There is a correlation bewteen the ability of these compounds to form granulomas after intradermal injection in the guinea-pig, their toxic effects on macrophages and fibroblasts and their haemolytic properties. A possible mechanism of toxicity of these compounds towards macrophages and fibroblasts is suggested.