Registration Dossier
Registration Dossier
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EC number: 265-996-3 | CAS number: 65996-65-8 The product of agglomerating iron ore fines, concentrates, iron sinter, and other iron-bearing materials. Includes pellets, nodules and briquettes.
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case report and review
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: case report and review
Data source
Reference
- Reference Type:
- publication
- Title:
- Metal fume fever: a case report and review of the literature.
- Author:
- Kaye P, Young H, O’Sullivan I
- Year:
- 2 002
- Bibliographic source:
- Emerg Med J 2002; 19:269-269
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- acute toxicity: inhalation
- Principles of method if other than guideline:
- case report
Test material
- Reference substance name:
- iron oxide
- IUPAC Name:
- iron oxide
- Details on test material:
- metal fume
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 1
- Sex: male
- Age: 55 - Ethical approval:
- not applicable
- Route of exposure:
- inhalation
- Reason of exposure:
- intentional, occupational
- Exposure assessment:
- not specified
- Details on exposure:
- working as a plumber and on the day of admission had been using an oxyacetylene torch to remove a steel tank
- Medical treatment:
- Oxygen therapy
Results and discussion
- Results of examinations:
- On examination, unable to talk in full sentences;
Respiratory rate was 24/min with an oxygen saturation of 94% in room air;
Chest examination was normal;
Pulse rate was 100/min and he was feverish at 39°C;
Blood gas analysis demonstrated acute type I respiratory failure with an arterial oxygen partial pressure of 8.8 kPa;
There was a neutrophil leucocytosis but no other abnormality of baseline pathology;
Chest radiograph revealed patchy opacification in the right perihilar area. - Effectivity of medical treatment:
- Full recovery within 1 day
- Outcome of incidence:
- Metal Fume Fever
Applicant's summary and conclusion
- Conclusions:
- According to the authors, Metal fume fever (MFF) is an acutely noxious inhalation syndrome secondary to metal oxide fumes. Despite preventative strategies sporadic cases are likely to continue to present to emergency departments. MFF is classically associated with zinc oxide fume exposure from welding galvanized steel or brass. It is also seen in association with high temperature zinc coating processes and metal pouring in brass foundries. Magnesium and copper oxide fumes are more rarely the causative agents.
- Executive summary:
- A case of Metal fume fever (MFF) is described and a short review of the literature on the background, pathogenesis, and clinical presentation of this syndrome is provided. According to the authors MFF is mainly associated with exposure to zinc oxide fume, rarely with magnesium and copper oxide fume. Iron oxide fume is not mentioned.
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