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EC number: 234-190-3 | CAS number: 10588-01-9
The results of the reviewed studies indicate that the dermal absorption of chromate from water soluble Cr (VI) compounds is likely to be low. Dermal absorption values of 1 -4% were found in guinea-pig studies, however these are likely to be over-estimates.
The dermal absorption of Cr (VI) has been stdueis in guinea pigs following the application of aqueous solutions of 51Cr-labelled chromate. Generally less than 1% of the dose was absorbed when animals were exposed to concentrations of between 0.48 mM and 4.87 M for 5 hours. At concentrations of 0.261 M and 0.398 M, 4% and 2.8% of the applied dose was absorbed, respectively. The UK IOH review cautions that, as dermal absorption was deteremined by measuring the disappearance of radiolabel from the applied dose, the reported figures include material residual in the skin at study termination. The reported dermal absorption figures may therefore be overestimates as material in the skin may not be systemically available.
An additional guinea pig study reported absorption (radioactivity in the carcass and excreta) of 1.4% after 24 hours; the findings of this study are therefore consistent with the earlier studies. Based on considerations of the comparative structure of human and guinea-pig skin, it can be concluded that the dermal absorption of water-soluble hexavalent chromium compounds in occupationally-exposed humans is likley to be negligible.
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