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Administrative data

Key value for chemical safety assessment

Additional information

All the data invitro indicate no mutagenic activity. In addition the single in vivo study on boric acid also indicated no mutagenic activity.

Justification for selection of genetic toxicity endpoint
No study is selected since all studies are negative.

Short description of key information:
In vitro gene mutation studies in bacteria (Stewart, 1991) in vitro gene mutation studies in mammalian cells (Rudd, 1991) and in vitro cytogenicity studies (NTP, 1987) concluded that boric acid is not genotoxic under the conditions of the studies. In addition the results of an in vivo bone marrow cytogenetic assay (chromosome aberration assay, O’Loughlin 1991) also showed boric acid to be non genotoxic.

Cytotoxicity observed at 5 mg/mL in the in vitro gene mutation studies in mammalian cells (Rudd, 1991).

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

No classification is required for boric oxide regarding genotoxicity as all results for boric acid were negative in the tests.