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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards with acceptable restrictions.

Data source

Reference
Reference Type:
publication
Title:
Boric acid ointment: A study of possible intoxication in the treatment of burns.
Author:
Pfeiffer CC, Hallman LF & Gersh I.
Year:
1945
Bibliographic source:
J. Amer. Med. Assoc. 128 (4) 266 - 274.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data
GLP compliance:
no
Remarks:
Study pre-dates GLP
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Boric acid
EC Number:
233-139-2
EC Name:
Boric acid
Cas Number:
10043-35-3
Molecular formula:
H3BO3
IUPAC Name:
Boric acid
Details on test material:
- Name of test material: Boric acid
- Molecular formula: H3BO3
- Molecular weight: 61.8
- Smiles notation:B(OH)3
- Substance type: Inorganic
- Physical state: Solid
- Analytical purity: > 99.9 % w/w
- Stability under test conditions: Stable
- Other: White and odourless.

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Doses:
No data
No. of animals per sex per dose:
45 animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 200 mg/kg bw
Based on:
test mat.
Clinical signs:
Pre-lethal symptoms in these animals were depression and ataxia (occasionally convulsions), fall in body temperature and violet-red colour of the skin and mucous membranes

Applicant's summary and conclusion

Conclusions:
The LD50 in guinea pigs was 1200 mg/kg bw
Pre-lethal symptoms in these animals were depression and ataxia (occasionally convulsions), fall in body temperature and violet-red colour of the skin and mucous membranes