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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
The protective roles of vitamins A and D against excess intake of boric acid in vivo.
Author:
Geyikoglu F, Turkez H, Topal A, Keles MS & Ozkan A
Year:
2006
Bibliographic source:
Proceedings of 3rd International Boron Symposium 02-04 November 2006, Ankara.

Materials and methods

Type of study / information:
The intraperitoneal effects of different boric acid concentrations were assessed.
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The intraperitoneal effects of different boric acid concentrations on concentrations of serum enzymes, haematological parameters and liver histology were assessed.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Boric acid
EC Number:
233-139-2
EC Name:
Boric acid
Cas Number:
10043-35-3
Molecular formula:
H3BO3
IUPAC Name:
Boric acid

Results and discussion

Applicant's summary and conclusion

Conclusions:
Haematological parameters slightly decreased with exposure to 750 mg/kg boric acid at 48 h but all values were not significantly different from controls. LDH and hepatocytes were unchanged. At low doses of boric acid levels of ALT, ALP and LDH as AST were unsignificantly decreased at 48 h.

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