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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: Case study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
other: Case study
Rationale for reliability incl. deficiencies:
other: Not applicable as this is a case study.

Data source

Reference
Reference Type:
publication
Title:
Accidental boric acid poisoning following the ingestion of household pesticide.
Author:
Hamilton RA & Wolf BC
Year:
2007
Bibliographic source:
J. Forensic Sci. 52 (3) 706 – 8

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: oral
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
The reference describes a poisoning incident in humans.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Boric acid
EC Number:
233-139-2
EC Name:
Boric acid
Cas Number:
10043-35-3
Molecular formula:
H3BO3
IUPAC Name:
Boric acid
Details on test material:
- Name of test material: Boric acid-containing roach powder.

Method

Subjects:
Number of subjects exposed: One
- Sex: Female
- Age: 18-months old
- Known diseases: The child had no documented past medical history.
Route of exposure:
oral
Reason of exposure:
accidental
Exposure assessment:
measured

Results and discussion

Clinical signs:
The child was pronounced dead at the emergency room. No clinical signs were therefore described.
Results of examinations:
A post-mortem examination was performed 28 h after the child’s death. The stomach contained 80 cc of thick green-brown liquid and the small and large intestines focally contained a light brown, liquid material. Routine toxicological studies were negative.  A heart-blood borate concentration of 8316 mcg/dL (reference range toxic > 2000 mcg/dL) and a gastric content borate concentration of 6048 mg/L. 

Applicant's summary and conclusion

Conclusions:
The case of an 18-month-old child who died following the accidental ingestion of boric acid-containing commercially available roach pesticide product was described. A post-mortem examination was performed 28 h after the child’s death. The stomach contained 80 cc of thick green-brown liquid and the small and large intestines focally contained a light brown, liquid material. Routine toxicological studies were negative. A heart blood borate concentration of 8316 mcg/dL (reference range toxic > 2000 mcg/dL) and a gastric content borate concentration of 6048 mg/L. The cause of death was attributed to accidental acute borax toxicity.