Registration Dossier
Registration Dossier
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EC number: 202-500-6 | CAS number: 96-33-3
Specific investigations: other studies
Administrative data
- Endpoint:
- cytotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study
Data source
Reference
- Reference Type:
- publication
- Title:
- Acrylate and methacrylate esters: Relationship of hemolytic activity and in vivo toxicity.
- Author:
- Dillingham EO et al.
- Year:
- 1 983
- Bibliographic source:
- J. Biomed. Mat. Res. 17: 945-957
Materials and methods
- Principles of method if other than guideline:
- According to Higuchi and Davis(1970) and Dillingham et al. (1973).
- GLP compliance:
- not specified
- Type of method:
- in vitro
Test material
- Reference substance name:
- Methyl acrylate
- EC Number:
- 202-500-6
- EC Name:
- Methyl acrylate
- Cas Number:
- 96-33-3
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methyl prop-2-enoate
- Details on test material:
- Methyl acrylate, no further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Results and discussion
- Details on results:
- The concentration effecting 50 % hemolysis in rabbit erythrocytes in vitro was determined to be 20 g/L (0.23 mole/L).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
