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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian cell study: DNA damage and/or repair
Remarks:
Type of genotoxicity: DNA damage and/or repair
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This is not a standard genotoxicity test system, but it provides evidence that acetic acid, sodium salt is not genotoxic in animals.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1981

Materials and methods

Principles of method if other than guideline:
This is not a routine genotoxicity test system. Method: 3H-thymidine incorporation measured.
GLP compliance:
no
Type of assay:
other: Testicular DNA-synthesis inhibition test (DSI test)

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium acetate
EC Number:
204-823-8
EC Name:
Sodium acetate
Cas Number:
127-09-3
Molecular formula:
C2H4O2.Na
IUPAC Name:
sodium acetate

Test animals

Species:
mouse
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 25- 30 g

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
A single administration
Frequency of treatment:
A single administration
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
200 mg/kg bw
Basis:
nominal conc.
Remarks:
Doses / Concentrations:
500 mg/kg bw
Basis:
nominal conc.
Remarks:
Doses / Concentrations:
1000 mg/kg bw
Basis:
nominal conc.
No. of animals per sex per dose:
No data on number of animals.
Control animals:
yes
Positive control(s):
No data

Examinations

Tissues and cell types examined:
3H-thymidine incorporation in testicular cells

Results and discussion

Test results
Sex:
male
Genotoxicity:
negative
Toxicity:
no effects
Vehicle controls validity:
valid
Positive controls validity:
not specified
Additional information on results:
No inhibitory effect on DNA-replication was detectable.

Any other information on results incl. tables

No inhibitory effect on DNA-replication was detectable.
    
    
    
    
    

No inhibitory effect on DNA-replication was detectable in animals treated with Sodium Acetate.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
No inhibitory effect on DNA-replication was detectable in animals treated with Sodium Acetate.
Executive summary:

The Testicular DNA-synthesis inhibition test (DSI test) was performed on male mice with Sodium Acetate. This is not a standard genotoxicity test system, but it provides evidence that acetic acid, sodium salt is not genotoxic in animals. The basis of the method is to measure 3H-thymidine incorporation. Animals receive a single oral dose by gavage at concentrations of 200, 500, and 1000 mg/kg bw of test substance.

No inhibitory effect on DNA-replication was detectable in animals treated with Sodium Acetate.