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EC number: 265-071-4 | CAS number: 64741-69-1 A complex combination of hydrocarbons from distillation of the products from a hydrocracking process. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C4 through C10, and boiling in the range of approximately minus 20°C to 180°C (-4°F to 356°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- GLP compliance:
- no
Test material
- Reference substance name:
- 64741-55-5
- Cas Number:
- 64741-55-5
- IUPAC Name:
- 64741-55-5
- Reference substance name:
- Light catalytically cracked naphtha
- IUPAC Name:
- Light catalytically cracked naphtha
- Test material form:
- other: low viscosity liquid hydrocarbon
- Details on test material:
- Density: 0.75 g/ml
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- dermal
- Duration of treatment / exposure:
- gestation days 0 to 19
- Frequency of treatment:
- once daily
- Duration of test:
- 19 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Dose levels of 30, 125 and 500 mg/kg/day
Basis:
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no effects
Details on maternal toxic effects:
Daily application of test material to the skin of pregnant rats during gestation produced dermal irritation at the application sites at all dose levels. The irritation ranged from slight to moderate. Maternal parameters (food consumption, body weight gain, serum chemistry) were monitored throughout gestation and showed no adverse trends. No adverse effects were observed on reproductive parameters (number of implants, resorptions, or viable fetuses)
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Details on embryotoxic / teratogenic effects:
No adverse effects were observed on fetal parameters (body weight or crown:rump length). No evidence of teratogenicity was observed in fetuses from pregnant dams exposed to the test material. It was concluded that dermal administration of light catalytically cracked naphtha does not adversely affect parameters of reproductive performance during gestation, nor does it adversely affect in utero survival and development of concepti.
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Based on the study results, the maternal NOAEL and the teratogenicity NOAEL were greater than 500mg/kg. These findings do not warrant the classification of light catalytically cracked naphtha as a developmental hazard under Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
- Executive summary:
Light catalytically cracked naphtha was administered once daily to pregnant rats on gestation days 0-19 via dermal application at doses of 30, 125, and 500 mg/kg to assess for developmental toxicity. Maternal parameters (food consumption, body weight gain, serum chemistry) were monitored throughout gestation and were not adversely affected by treatment. No adverse effects were observed on eproductive parameters (number of implants, resporptions, or viable fetuses) or on fetal parameters (body weight or crown:rump length). No evidence of teratogenicity was observed in fetues from pregant dams exposed to the test material. Based on the study results, the maternal NOAEL and the teratogenicity NOAEL were greater than 500mg/kg. These findings do not warrant the classification of light catalytically cracked naphtha as a developmental hazard under Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
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