Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
The result is sourced from secondary literature (IUCLID). The original reference was not available for review and no further information is available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Subacute study with emphasis on lung
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Octamethylcyclotetrasiloxane
EC Number:
209-136-7
EC Name:
Octamethylcyclotetrasiloxane
Cas Number:
556-67-2
Molecular formula:
C8H24O4Si4
IUPAC Name:
2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
up to 5 days
Frequency of treatment:
daily
Doses / concentrations
Dose / conc.:
1 000 mg/kg bw (total dose)
No. of animals per sex per dose:
Two females
Control animals:
no
Details on study design:
Post-exposure period: no

Results and discussion

Results of examinations

Gross pathological findings:
no effects observed

Effect levels

Dose descriptor:
NOAEL
Effect level:
>= 1 000 mg/kg bw/day
Based on:
test mat.
Sex:
female

Target system / organ toxicity

Critical effects observed:
no

Any other information on results incl. tables

No effects in lungs or other organs of the viscera

Applicant's summary and conclusion

Conclusions:
In a limited study only available as a IUCLID summary (reliability score 4) and not to GLP, there was no effect on the lungs or other organs of the viscera in rabbits following daily intraperitoneal injections of 1000 mg/kg bw/day D4, for up to five days.