Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

No neurotoxicity study is available. However, a two-generation inhalation reproductive toxicity (WIL Research Laboratories, 2001a;Siddiqui, W. al.2007) and developmental neurotoxicity study of octamethylcyclotetrasiloxane (D4) in rats (Research and Development Corporation, 1993a; York, R. and Schardein, J. L. 1994a) and several repeated dose toxicity studies (Batelle (2004) revealed no signs of neurotoxicity.

There were no histomorphological evidence of neurotoxicity.

Key value for chemical safety assessment

Additional information

Justification for classification or non-classification