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EC number: 231-890-0
CAS number: 7775-14-6
The interaction of sulfite and the
superoxide radical anion (O2^-) formed during the oxidative burst in the
leukocytes was also investigated. The formation of O2^- was estimated by
measuring the reduction of cytochrome C. Sulfite efficiently inhibited
the reduction of cytochrome C by cells with low sulfite oxidase
activity. For instance in the presence of 1 mM sulfite the inhibition
was more than 80%. The reason is possible an interaction between O2^-
and sulfite leading to sulfur trioxide radical formation. The effect on
cytochrome C reduction by sulfite in leukocytes with high sulfite
oxidase activity is minor. Due to the very rapid enzymatic oxidation of
sulfite to sulfate only limited interction between sulfite and O2^-
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