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Registration Dossier
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EC number: 500-066-5 | CAS number: 28961-43-5 1 - 6.5 moles ethoxylated
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 13, 1984 to April 11, 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An acute dermal toxicity study was performed in rabbits. The test material was administered at a single dose level and observations were made for a period of 7d.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- ethoxylated trimethylolpropane triacrylate (TMPeoTA)
- IUPAC Name:
- ethoxylated trimethylolpropane triacrylate (TMPeoTA)
- Reference substance name:
- Propylidynetrimethanol, ethoxylated, esters with acrylic acid
- EC Number:
- 500-066-5
- EC Name:
- Propylidynetrimethanol, ethoxylated, esters with acrylic acid
- Cas Number:
- 28961-43-5
- Molecular formula:
- n.a.
- IUPAC Name:
- Poly(oxy-1,2-ethanediyl),.alpha.-hydro-.omega.-[(1-oxo-2- propenyl)oxy]-, ether with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (3:1)
- Details on test material:
- - Substance type: Pure active substance
- Physical state: Very light amber liquid
- Analytical purity: 100 %
- Storage condition of test material: 15.55-29.44 °C
- Other: Density: 1.1 g/mL
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- IN-LIFE DATES: From: 1984-02-13 to: 1984-08-03
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 12000 mL/kg bw - Duration of exposure:
- No data
- Doses:
- 13200 mg/kg bw
- No. of animals per sex per dose:
- Four
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 d
- Statistics:
- No data
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 13 200 mg/kg bw
- Mortality:
- None
- Clinical signs:
- other: Lack of food consumption was reported in one animal on days 5 and 6.
- Gross pathology:
- No data
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- The acute dermal LD50 of ethoxylated trimethylolpropane triacrylate (TMPeoTA) was determined to be >13,200 mg/kg bw in rabbits.
- Executive summary:
A study was conducted to evaluate the acute dermal toxicity of ethoxylated trimethylolpropane triacrylate (TMPeoTA) in albino rabbits. A dermal application of 13,200 mg/kg TMPeoTA was applied to 4 rabbits. Parameters evaluated included mortality, clinical observations and body weight for a period of 7 days. No mortality was observed. Lack of food consumption was reported in one animal on days 5 and 6. In conclusion, the single dermal median lethal dose (LD50) of TMPeoTA was determined to be >13,200 mg/kg bw in rabbits.
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