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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From February 13, 1984 to April 11, 1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
An acute dermal toxicity study was performed in rabbits. The test material was administered at a single dose level and observations were made for a period of 7d.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
ethoxylated trimethylolpropane triacrylate (TMPeoTA)
IUPAC Name:
ethoxylated trimethylolpropane triacrylate (TMPeoTA)
Constituent 2
Chemical structure
Reference substance name:
Propylidynetrimethanol, ethoxylated, esters with acrylic acid
EC Number:
500-066-5
EC Name:
Propylidynetrimethanol, ethoxylated, esters with acrylic acid
Cas Number:
28961-43-5
Molecular formula:
n.a.
IUPAC Name:
Propylidynetrimethanol, ethoxylated, esters with acrylic acid
Details on test material:
- Substance type: Pure active substance
- Physical state: Very light amber liquid
- Analytical purity: 100 %
- Storage condition of test material: 15.55-29.44 °C
- Other: Density: 1.1 g/mL

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
IN-LIFE DATES: From: 1984-02-13 to: 1984-08-03

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 12000 mL/kg bw
Duration of exposure:
No data
Doses:
13200 mg/kg bw
No. of animals per sex per dose:
Four
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 d
Statistics:
No data

Results and discussion

Preliminary study:
Not applicable
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 13 200 mg/kg bw
Mortality:
None
Clinical signs:
Lack of food consumption was reported in one animal on days 5 and 6.
Body weight:
No data
Gross pathology:
No data
Other findings:
None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
not classified
Conclusions:
The acute dermal LD50 of ethoxylated trimethylolpropane triacrylate (TMPeoTA) was determined to be >13,200 mg/kg bw in rabbits.

Executive summary:

A study was conducted to evaluate the acute dermal toxicity of ethoxylated trimethylolpropane triacrylate (TMPeoTA) in albino rabbits. A dermal application of 13,200 mg/kg TMPeoTA was applied to 4 rabbits. Parameters evaluated included mortality, clinical observations and body weight for a period of 7 days. No mortality was observed. Lack of food consumption was reported in one animal on days 5 and 6. In conclusion, the single dermal median lethal dose (LD50) of TMPeoTA was determined to be >13,200 mg/kg bw in rabbits.