Registration Dossier
Registration Dossier
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EC number: 204-826-4 | CAS number: 127-19-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
Considering the toxicity of N,N-dimethylacetamide to aquatic invertebrates there are experimental data from two studies for each, the freshwater and marine compartment available.
Freshwater data:
- In a static test conducted according to EU method C.2., using D. magna as test organism, a 48-h EC50 of >500 mg/L was determined, based on nominal test concentrations (BASF AG, 1988; report no. 1/1021/2/88-1021/88). These data were selected as freshwater-key data.
- In a supporting acute toxicity test (guideline not specified in study report) with D. magna as test organism, the 48-h EC50 was >1000 g/L (nominal, Adema, 1987; cited in OECD SIDS, 2001).
Marine data:
- A semi-static acute toxicity test (guideline not specified in study report) was conducted using Americamysis bahia (former: Mysidopsis bahia) as test organism. Based on nominal test concentrations the 96-h EC50 was found to be 966 mg/L (Adema, 1987; cited in OECD SIDS, 2001). These data were selected as key-marine data.
- In a further acute toxicity test conducted under marine conditions (guideline not specified in study report) the test organism was chaetogammarus marinus. After an exposure period of 96 h the EC50 was determined to be >1000 mg/L, supporting the results of the marine key study (Adema, 1987; cited in OECD SIDS, 2001).
In conclusion, the substance is assessed to be with probability acutely not harmful to aquatic invertebrates.
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