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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Na-succinate, and by this succinic acid, was of low toxicity in a 90-day study and a 2-years study with administration in drinking water to rats.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
860 mg/kg bw/day
Study duration:
chronic
Species:
rat

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEC
1 130 mg/m³
Study duration:
chronic
Species:
rat

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
860 mg/kg bw/day
Study duration:
chronic
Species:
rat

Additional information

Justifications for a read-across from data of monosodium succinate to succinic acid:

The read-across from the succinate to succinic acid seems justified, as both are well water soluble and will be in the ionised form in dilute aqueous solutions, to give the same anion. The different molecular weights were considered.

Justification for classification or non-classification

No classification is derived from the NOAELs.