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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity: LD50 2650 mg/kg bw (standard acute method)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
2 650 mg/kg bw

Additional information

An acute oral toxicity was performed according to the standard acute method. Rats were treated with Cinnamon leaf oil by oral administration at 5 doses (1640, 2050, 2560, 3200, and 5000 mg/kg), 10 rats per dose. The animals were observed daily during test days 1-14, and mortality and clinical signs were recorded. Based on the results an LD50 of 2650 mg/kg bw was established.

A supporting study was available in which cinnamon leaf oil was administered dermally to New Zealand White rabbits. A limit dose of 5000 mg/kg bw did not result in mortality, and the LD50 was determined to be >5000 mg/kg bw.

Justification for classification or non-classification

Based on the available information, cinnamon leaf oil has been shown to be of low acute toxicity when applied via the oral and dermal route. Therefore, the substance cinnamon leaf oil does not need to be classified for acute toxicity according to the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).