Registration Dossier
Registration Dossier
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EC number: 203-905-0 | CAS number: 111-76-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Only studies considered reliable are listed here:
Oncorhynchus mykiss/S Gairdneri LD50=1474mg/l; LC0>1000mg/l
Leopomis macrochirus. 96hr LC50=1490mg/l (protocol: no data)
Menidia beryllina 96hr LC50 =1250mg/l (protocol: no data)
Leuciscus melanotus. 48hr LC50 >1395-1575mg/l (protocol: no data)
Poecilia reticulata. 7 day LC50 8.3mmol/l (protocol. no data)
Carrasius auratus 24hr LC50=1700mg/l (protocol. no data)
Pimephales promelas 96hr LC50=2137mg/l, 1700, 1580 (protocol: US EPA)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 474 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 1 250 mg/L
Additional information
A number of reliable acute toxicity studies in fish have been carried out using multiple species, both fresh and salt water. A number of these have data for the required 96 hour exposure period. All the data available span a remarkably small range of values strongly suggesting a mode of action based on narcosis rather than a substance specific toxicity. The study reporting the lowest LD50 is used to derive the key parameter, which is also a good quality study for freshwater fish. This study also provides the lowest value from the 96hr studies. A second study providing data on saltwater fish is also considered reliable and is used as the source for the key parameter for marine water fish. Even data available from sources that are not regarded as robust, provide consistent support for the reliable studies. It can be concluded that 2 -butoxyethanol is practically non-toxic to fish over the acute timeframe.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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