Registration Dossier
Registration Dossier
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EC number: 203-905-0 | CAS number: 111-76-2
Endpoint summary
Administrative data
Description of key information
Additional information
A number of studies have been carried out using multiple species of fish, both fresh and salt water. A guideline study in freshwater fish that is available as both the original study and a publication along with a second study in a saltwater species are sufficiently well reported to judge them as reliable and are used to derive the key parameters. All the other available experimental studies, are highly consistent with the key studies and provide evidence to support a narcotic mode of action and an indication that 2 -butoxyethanol is essentially non-toxic to fish over the acute timeframe. The acute LC50 value is 1464mg/l in freshwater fish. In a 21 day study in fish (Brachydanio rerio) that was designed to examine the potential for endocrine disrupting effects and which was based around the OECD guideline, there was no evidence of any adverse effects, including on endocrine markers, up to and including the maximum tested dose of 100mg/l.
A number of studies have been carried out using multiple species of invertebrates, both fresh and salt water. These indicate that 2 -butoxyethanol is of low toxicity to invertebrates. Some of these studies were not performed for the normally required 48hrs (only 24hr studies) however one study was for the requisite period and to a modern protocol and in the preferred daphnia magna species. Since this produced the lowest value (except for one study for which full details are not available and which showed some inconsistency in the results) it is selected as a key study. In addition, there is reliable data in a seawater species. (albeit only a 24hr study). There are also 2 studies available using hydra species. Since one of these gave a lower IC50 value than daphnia, it is used to derive the acute PNEC for this species. Two chronic studies are available in invertebrates. Both gave reasonably consistent results. The 21 day study in daphnia magna is considered the most reliable as this is a full guideline study with no significant shortcomings.
A small number of algal toxicity studies are available. Two of them are considered key studies suitable to derive the key parameter for this end point.
A number of studies have been carried out to assess the toxicity of 2 -butoxyethanol to micro-organism using multiple species of protozoa and bacteria in fresh water. The studies that are reliable indicate that the substance may be slightly toxic to micro-organisms. The weight of evidence suggested that the substance is generally of low toxicity.
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