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EC number: 203-366-1 | CAS number: 106-14-9
A study was conducted to evaluate the teratogenicity effects of the test substance on Charles River Crl:CD VAF/Plus female rats.
The test substance was applied to dorsal skin of two groups of 30 mated female rats. Applications were made on gestation Days 6 through 15, once daily, and left on for 6 h each day. The control article was similarly applied to an additional group of rats of the same strain. All surviving animals were killed on Day 20 of gestation. Following additional parameters were evaluated: implantations, postimplantation losses, corporea lutea, fetal sex ratio, mean fetal body weight or uterine weight, malformations and developmental variations.
There were no significant differences in clinical or necropsy observation between experimental and control groups.
There were no test-article related or statistically significant differences in the incidence of of fetal malformations or fetal developmental variations between experimental and control groups.
Under the test conditions, no maternal or developmental toxicity was observed after repeated application of hydroxystearic acid on rat. Therefore, the NOEL value of the test substance for maternal and developmental toxicity was determined to be equal or more than 7%.
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