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Diss Factsheets
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EC number: 203-812-5 | CAS number: 110-88-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1968
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Remarks:
- ; GLP was not compulsory at the time the study was conducted
- Limit test:
- no
Test material
- Reference substance name:
- 1,3,5-trioxane
- EC Number:
- 203-812-5
- EC Name:
- 1,3,5-trioxane
- Cas Number:
- 110-88-3
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 1,3,5-trioxane
- Details on test material:
- 1,3,5-Trioxan
Purity: 99.99%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Designation: Kisslegg mice
Source: no data
Age at test initiation: no data
Bodyweight range at test initiation: males, 31 - 42 g, females, 19 - 33 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Traganth
- Details on exposure:
- - Before administration, the test substance was finely pulverised and an aqueous solution of 2% and 16% was prepared in Traganth.
- The 2% solution was employed for the preparation of the 200 mg/kg bw dose;
- The 16% suspension was used for the preparation of the 1600 mg/kg bw, the 2000 mg/kg bw and the 2500 mg/kg bw doses;
- Suspensions over 16% were not applicable because the application syringe was clogged;
- Application volume for the doses 200 mg/kg bw and 1600 mg/kg bw was 10 ml/kg bw;
- Application volume for the dose 2000 mg/kg bw was 12.5 ml/kg bw;
- Application volume for the dose 2500 mg/kg bw was 15.6 ml/kg bw. - Doses:
- 200, 1600, 2000 and 2500 mg/kg bw
- No. of animals per sex per dose:
- 5 animals/sex/dose
- Control animals:
- no
- Details on study design:
- A single dose of the test substance was injected into the peritoneal cavity of each animal;
The animals from the 200 and 1600 mg/kg bw dose groups were observed for a period of 7 days while the animals administered the doses 2000 and 2500 mg/kg bw were under observation for 14 days;
Animals that died during the observation period were necropsied. At the end of the observation period, surviving animals were sacrificed and subjected to necropsy. - Statistics:
- No data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 800 mg/kg bw
- Remarks on result:
- other: LD 50 after 14 days
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 300 mg/kg bw
- Remarks on result:
- other: LD 50 after 7 days
- Mortality:
- 2500 mg/kg bw: mortality was 7/10 animals after 7 days which reached 8/10 after 14 days
2000 mg/kg bw: mortality was 3/10 animals after 7 days which reached 9/10 after 14 days
1600 mg/kg bw: mortality was 2/10 animals after 7 days
200 mg/kg bw: No mortality was observed. - Clinical signs:
- 2000 and 2500 mg/kg bw:
Symptoms observed immediately after application included weak jumping convulsions, accelerated respiration, closed eyes, impaired movement of the rear limbs, high stepping gait. The symptoms lasted the entire day after application.
One day after application symptoms included prone position, apathy, sticky eyes and unkempt fur.
On day 7 after application, the surviving animals began recovering. From day 9 to day 14, no more symptoms were seen.
200 and 1600 mg/kg bw:
Symptoms observed immediately after application of the test substance included irregular respiration and high stepping gait with lagging hind limbs.
On day 2 after application, symptoms included unkempt fur, apathy, closed eyes, intermittent respiration and prone position.
After 5 days, the surviving animals demonstrated no more symptoms. - Body weight:
- No data
- Gross pathology:
- Results for animals that died during the observation period:
Granular substance incorporations were found between the intestinal loops of 1 female treated with 2500 mg/kg bw dose. Similar incorporations were also seen at 2000 mg/kg bw (2 males). Intraabdominal adhesions were observed in 3 animals treated with 2500 mg/kg bw (both sexes) as well as in 7 animals treated with 2000 mg/kg bw (both sexes).
Of the 2 animals that died in the 1600 mg/kg bw group, putrefaction was observed in 1 female. No documentation was available for the second animal.
Results for animals that were sacrificed:
In the 2500 mg/kg bw group, necropsy of the sacrificed animals (1 male and 1 female) revealed compact intraabdominal adhesions in both animals.
No necropsy documentation was available for the only surviving animal in the 2000 mg/kg bw group.
Intraabdominale adhesions were observed in the surviving animals of the 200 mg/kg bw (5 males, 5 females) and 1600 mg/kg bw (4 males, 4 females) groups.
Any other information on results incl. tables
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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