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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
2008
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only information of a secondary source is available (SIAR 2008).

Data source

Reference
Reference Type:
secondary source
Title:
Barium chloride - Initial assessment profile
Author:
Anonymous
Year:
2008
Bibliographic source:
SIAM 27
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Barium chloride
EC Number:
233-788-1
EC Name:
Barium chloride
Cas Number:
10361-37-2
Molecular formula:
BaCl2
IUPAC Name:
barium dichloride
Details on test material:
no futher details

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
no data
Duration of exposure:
no data
Doses:
2000 mg/kg bw.
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: secondary literature
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to the SIAR , an acute dermal toxicity study on barium chloride was conducted under OECD TG 402 in compliance with GLP: in this study, the dermal LD50 was greater than 2000 mg/kg bw in rats. However, the primary source for this study is not available: the SIAR refers to a NIER report dated 2008.
Executive summary:

Read-across BaCl2 to BaSO4:

The toxicity of barium sulfate and barium chloride is based on the concentration of dissolved Ba2 + and therefore on the water solubility of each substance. Barium chloride is known to be well water soluble whereas barium sulfate is low soluble in water. The conclusion is that Ba2+ ions are more bioavailable if BaCl2 is administered as if BaSO4 is administered. Hence, read across to BaSO4 based on worst case consideration and will likely lead to rather conservative no-effect levels.

Due to the fact that Barium chloride seems to be no toxic via the dermal route it can be concluded that barium sulfate has a dermal LD50 of >2000 mg/kg bw and should therefore not classified as acute toxic to the dermal route.

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