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EC number: 231-784-4 | CAS number: 7727-43-7
Nanomaterial dustiness
Administrative data
- Endpoint:
- nanomaterial dustiness
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not specified
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 55992-1 (Determination of a parameter for the dust formation of pigments and extenders - Part 1: Rotation method)
- Version / remarks:
- 2006
- Deviations:
- yes
- Remarks:
- Heubach dust meter was connected to a seven stage cascade impactor.
- GLP compliance:
- no
- Type of method:
- rotating cylinder
- Details on methods and data evaluation:
- The Heubach dust meter is modified in a way that a seven stage cascade impactor is connected to the system. This involves an additional air fed of 20 L/min via the coarse dust seperator needed to supply the cascade impactor with 40 L/min air current as specified in the manufacturer's specifications.
The calculation report: EBRC (2021)
The Multiple-Path Particle Dosimetry Model (MPPD, v3.01; ARA (2015)) was used to predict this fractional deposition behaviour for workers.
The model algorithms calculate the deposition (and clearance) of mono-disperse and polydisperse aerosols in the respiratory tract for particles ranging from ultra-fine (0.01 microns) to coarse (20 microns) sizes. Within each airway, the deposition is calculated using theoretically derived efficiencies for deposition by diffusion, sedimentation and impaction within the airway or airway bifurcation. Filtration of aerosols by the head is determined using empirical efficiency functions. - Sampling:
- please refer to the field `Any other information on materials and methods incl. tables´
Test material
- Reference substance name:
- Barium sulfate
- EC Number:
- 231-784-4
- EC Name:
- Barium sulfate
- Cas Number:
- 7727-43-7
- Molecular formula:
- BaO4S
- IUPAC Name:
- barium sulfate
- Test material form:
- solid: nanoform
- Details on test material:
- Trade name: Sachtoperse HP
Appearance: solid, white powder
Molecular weight: 233.39 g/mole
EC-No.: 231-784-4
CAS-No.: 7727-43-7
Appearance: Solid, white odourless powder
Relative density: 4.35
Substance humidity: 0.06 % (by DMT)
Substance stability: Stable under normal conditions
Constituent 1
Data gathering
- Instruments:
- Heubach dust meter was connected to a seven stage cascade impactor.
- Calibration:
- not specified
- Reproducibility:
- not specified
Results and discussion
Dustiness indexopen allclose all
- Mean:
- 1.27 other: mg/g
- Remarks on result:
- other: respirable fraction, no st.dev. stated
- Mean:
- 4.39 other: mg/g
- Remarks on result:
- other: thoracic fraction, no st.dev. stated
- Mean:
- 14.54 other: mg/g
- Remarks on result:
- other: inhalable fraction; no st.dev. stated
- Mean:
- 23.49 other: mg/g
- Remarks on result:
- other: total dustiness; no st.dev. stated
Any other information on results incl. tables
Dustiness (airborne fraction): total: 23.49 mg/g.
In the original study report by DMT, a calculation of the mass median diameter was not conducted. Since the deposited fractions were provided for each of the cascade impactor stages, it was possible to fit a monomodal lognormal distribution to the data by standard non-linear regression procedure. As a result, the MMAD and GSD are calculable and reported (MMAD = 31.24 µm, GSD = 2.97).
As the cascade impactor already takes aerodynamic characteristics of the particles into account, the reported mass median diameter can be interpreted as the mass median aerodynamic diameter.
This figure and the corresponding GSD were used as distribution parameters for the MPPD model enabling an estimation of deposited dust fractions in the human respiratory tract: These fractions were estimated as follows:
Head (ET): 46.10 %
Tracheobronchial (TB): 0.29 %
Pulmonary (PU): 0.61 %
Applicant's summary and conclusion
- Conclusions:
- Experimental results (DMT Report)
Total Dustiness (airborne fraction): 23.49 mg/g,
Inhalable fraction: 14.54 mg/g,
Thoracic fraction: 4.39 mg/g,
Respirable fraction: 1.27 mg/g
Mass median aerodynamic diamater of airborne fraction: MMAD= 31.24 µm
Geometric standard deviation of MMAD: GSD= 2.97
Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):
Head (ET): 46.10 %
Tracheobronchial (TB): 0.29 %
Pulmonary (PU): 0.61 %
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