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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Well documented, scientifically sound study according to a method similar to OECD 401 "Acute Oral Toxicity" with the following deviations: (1) The number of deaths at each dose were not reported; (2) the specific doses (mg/kg) were not provided; (3) individual clinical observations, body weights, pathology were not reported; (4) sex of the animals was not provided.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1950

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
see rationale for reliability
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Zirconium dichloride oxide
EC Number:
231-717-9
EC Name:
Zirconium dichloride oxide
Cas Number:
7699-43-6
Molecular formula:
Cl2OZr
IUPAC Name:
Dichloro(oxo)zirconium
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): zirconium oxychloride
- Physical state: crystals

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: Adults
- Weight at study initiation: 200 - 300 g
- Diet (e.g. ad libitum): ad libitum, purina chow
- Water (e.g. ad libitum): ad libitum
- Fasting period before study: no data
- Housing: maintained in air-conditioned rooms


Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 50%

Doses:
Specific doses administered were not provided
No. of animals per sex per dose:
22 rats were used (sex of the animals was not provided)
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 10 days, an initial group of animals receiving the test subsance was kept for 30 days to verify if any significant mortality occurred after the tenth day.
Statistics:
The LD50 values were obtained from 10-day mortality data by using the log-probability method.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 3 500 other: mg/kg bw
Based on:
test mat.
Mortality:
The LD50 was calculated to be 3500 mg compound/kg (990 mg metal/kg). The time of death varied from a few hours to a few days following the exposure to the test substance. Few deaths were reported later than five days after exposure to test substance. Individual animal data were not provided.
Clinical signs:
Animals exposed to the test substance showed a progressive depression and decrease in activity until death occurred.
Gross pathology:
No gross pathological changes were reported in any of the animals receiving lethal doses of the test substance.
Other findings:
No physiologic changes were reported in any of the animals receiving lethal doses of the test substance.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral LD50 in rats via gavage was calculated to be 3500 mg/kg bw for zirconium dichloride oxide.