Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-733-9 | CAS number: 69012-33-5 By-product of the manufacture of silicomanganese alloy containing oxides of aluminum, calcium, magnesium, manganese and silicon.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-11-3 to 2009-11-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to valid guidelines and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Slags, silicomanganese-manufg.
- EC Number:
- 273-733-9
- EC Name:
- Slags, silicomanganese-manufg.
- Cas Number:
- 69012-33-5
- Molecular formula:
- UVCB identified to contain the following formulae: Na2O, MgO, Al2O3, SiO2, P2O5, K2O, CaO, TiO2, V2O5, Cr2O3, Fe2O3,BaO, ZrO2, ZnO, SrO, SiMn
- IUPAC Name:
- Slags, silicomanganese-manufacturing
- Details on test material:
- - Name of test material : SiMn slag
- Physical state: solid
- Appearance: light grey granules
- Storage condition of test material: room temperature in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Limited, Hillcrest, Belton, Loughborough, UK
- Age at study initiation: 12 to 20 weeks old
- Weight at study initiation: 2.45 to 2.61 kg
- Housing: Individually housed in suspended cages
- Diet: 2030 Teklad Global Rabbit diet (Harlan Teklad, Blackthorn, Bicester, Oxon, UK) available ad libitum.
- Water: Mains drinking water available ad libitum.
- Acclimation period: Minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 to 23 °C
- Humidity (%): 30 to 70 %
- Air changes (per hr): A minimum of 15 changes per hour
- Photoperiod (hrs dark / hrs light): 12 hour cycle
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST SUBSTANCE
- Amount(s) applied : 0.5 g of test substance sufficiently moistened in 0.5 mL of distilled water to achieve a paste. - Duration of treatment / exposure:
- Animal were exposed for 4 hours
- Observation period:
- Animals were observed for 72 hours for skin reactions
- Number of animals:
- 3 animals in total (1 animal used in the initial test, with a further 2 animals in the main test.)
- Details on study design:
- TEST SITE
- Area of exposure: The test substance was introduced a 2.5 cm x 2.5 cm cotton gauze patch
- Type of wrap if used: The trunk of each rabbit was wrapped in an elasticated corset
REMOVAL OF TEST SUBSTANCE
- Washing : Any residual test substance was removed by gentle swabbing with cotton wool soaked in distilled water
- Time after start of exposure: 4 hours post administration of test substance
SCORING SYSTEM: Draize JH (1959) “Dermal Toxicity” In: Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. Associations of Food and Drug Officials of the United States, Austin, Texas p.46-59
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of three animals
- Time point:
- other: 24, 48 and 72 hours post dosing
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: Not applicable, no effects were noted during the study.
- Irritant / corrosive response data:
- The test substance produced a primary irritation index of 0.0.
- Other effects:
- Not reported
Any other information on results incl. tables
Measurement of pH
The pH of the test substance was determined prior to commencement of the study and found to be as follows:
Preparation |
pH Measurement |
|
immediately |
after 10 minutes |
|
10 % w/w aqueous preparation of the test substance |
8.1 |
8.3 |
Table 1: Individual Skin Reactions
Skin Reaction |
Observation Time (Following Patch Removal) |
Individual Scores – Rabbit Number and Sex |
Total |
||
68639 Male |
68640 Male |
68655 Male |
|||
Erythema/Eschar Formation |
Immediately |
0 |
0 |
0 |
(0) |
1 hour |
0 |
0 |
0 |
(0) |
|
24 hours |
0 |
0 |
0 |
0 |
|
48 hours |
0 |
0 |
0 |
(0) |
|
72 hours |
0 |
0* |
0* |
0 |
|
Oedema Formation |
Immediately |
0 |
0 |
0 |
(0) |
1 hour |
0 |
0 |
0 |
(0) |
|
24 hours |
0 |
0 |
0 |
0 |
|
48 hours |
0 |
0 |
0 |
(0) |
|
72 hours |
0 |
0* |
0* |
0 |
|
Sum of 24 and 72-hour Readings (S): 0 |
|||||
Primary Irritation Index (S/6): 0/6 = 0.0 |
|||||
Classification: Non-Irritant |
() = total values not included in calculating the primary irritation index
Table 2: Individual Bodyweights and Bodyweight Changes
Rabbit Number and Sex |
Individual Bodyweight (kg) |
Bodyweight Change (kg) |
|
Day 0 |
Day 3 |
||
68639 Male |
2.45 |
2.54 |
0.09 |
68640 Male |
2.61 |
2.65 |
0.04 |
68655 Male |
2.52 |
2.64 |
0.12 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study the test substance was determined to be not classified for skin corrosion and irritation.
- Executive summary:
The skin corrosion and irritation potential of the test substance was determined in an in vivo study which was conducted under GLP conditions and in accordance with the standardised guidelines OECD 404 and EU Method B.4.
During the study, 0.5 g of test substance, sufficiently moistened in 0.5 mL of distilled water to achieve a paste, was applied to the shaved trunk of three male rabbits. The test substance was held in place under a semiocclusive dressing. Four hours following topical administration, any residual test substance was removed by gentle swabbing with cotton wool soaked in distilled water. Skin reaction to treatment was assessed over a period of 72 hours according to the Draize scale.
None of the animals died during the study and all animals gained weight. No erythema or oedema was observed following treatment with the test substance. Therefore, under the conditions of the study the test substance was determined to be not classified for skin corrosion and irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.