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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, comparable to guideline; minor restrictions in design and/or reporting but otherwise adequate for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1982
Reference Type:
study report
Title:
Unnamed
Year:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1-difluoroethylene
EC Number:
200-867-7
EC Name:
1,1-difluoroethylene
Cas Number:
75-38-7
Molecular formula:
C2H2F2
IUPAC Name:
1,1-difluoroethene

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
200,000 ppm
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
Animals were observed for 7 days after exposure.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LCLo
Effect level:
> 200 000 ppm
Exp. duration:
1 h
Remarks on result:
other: Animals were observed for 7 days after exposure, no effects were noted
Mortality:
No mortality was observed.
Clinical signs:
other: No respiratory and skeletal reflex changes were observed. The animals remained alert and responsive to environmental stimuli.
Body weight:
No loss in body weight was observed.
Gross pathology:
No gross pathological changes were observed.

Applicant's summary and conclusion