Registration Dossier
Registration Dossier
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EC number: 203-441-9 | CAS number: 106-91-2
Neurotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Neurotoxicity
Fischer 344 rats were exposed by inhalation to glycidyl methacrylate at approximately 0.5, 2 or 15 ppm (2.9, 12, 87 mg/m3), 6 hours/day, 5 days/ week for 13weeks (calculated daily dose: 0.35, 1.46, 10.59 mg/kg/day). At week 4, there was a low incidence of rat with nasal discharge and enlarged nostrils at 2 and 15 ppm. There were no other treatment-related effects. A functional observation battery (FOB) and motor activity (MA) were conducted preexposure and at the end of each month of exposure. In addition, the postexposure neurotoxicity evaluation focused on evoked potential testing of the visual (FEP), auditory (ABR), somatosensory system (SEP), and caudal nerves (CNAP), and a comprehensive neuropathological examination.
There was no evidence of neurotoxic effects at any exposure level. (Mattsson et al.: 1996)
Justification for classification or non-classification
Based on the available studies classification under REACH and CLP of glycidyl methacrylate is not required.
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